The ability of natural tolerance to be applied to allogeneic tissue: determinants and limits |
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| Authors: | William FN Chan Ainhoa Perez-Diez Haide Razavy Colin C Anderson |
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| Institution: | (1) Department of Surgery, Surgical-Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada;(2) Department of Medical Microbiology and Immunology, Surgical-Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada;(3) Ghost Lab, Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA |
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| Abstract: | Background Transplant rejection has been considered to occur primarily because donor antigens are not present during the development
of the recipient's immune system to induce tolerance. Thus, transplantation prior to recipient immune system development (pre-immunocompetence
transplants) should induce natural tolerance to the donor. Surprisingly, tolerance was often not the outcome in such 'natural
tolerance models'. We explored the ability of natural tolerance to prevent immune responses to alloantigens, and the reasons
for the disparate outcomes of pre-immunocompetence transplants. |
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