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Structure comparisons of Aedes albopictus densovirus with other parvoviruses |
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| Authors: | Cheng LingPeng Chen SenXiong Z. H. Zhou Zhang JingQiang |
| Affiliation: | 1. Department of Biomedical Engineering, School of Bioscience & Bioengineering, South China University of Technology, Guangzhou 510640, China;State Key Laboratory of Biocontrol, Sun Yat-sen University, Guangzhou 510275, China 2. State Key Laboratory of Biocontrol, Sun Yat-sen University, Guangzhou 510275, China 3. Department of Pathology & Laboratory Medicine, University of Texas Medical School at Houston, Houston, TX77030, USA |
| Abstract: | Parvoviridae is a family of the smallest viruses known with a wide variety of hosts. The capsid structure of the Aedes albopictus C6/36 cell densovirus (C6/36 DNV) at 1.2-nm resolution was obtained by electron cryomicroscopy (cryoEM) and three-dimensional (3D) image reconstruction. Structure comparisons between the C6/36 DNV and other parvoviruses reveal that the degree of structural similarity between C6/36 DNV and the human parvovirus B19 is higher than that between C6/36 DNV and other insect parvoviruses. The amino acid sequence comparisons of structural and non-structural proteins also reveal higher levels of similarity between C6/36 DNV and parvovirus B19 than those between C6/36 DNV and other parvoviruses. These findings indicate that C6/36 DNV is closely related to the human virus B19, and the former might evolve from the human species other than from other insect viruses. |
| Keywords: | densovirus three-dimensional structure amino acid sequence |
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