Molecular Evolution of Peptide Methionine Sulfoxide Reductases (MsrA and MsrB): On the Early Development of a Mechanism That Protects Against Oxidative Damage |
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Authors: | Luis Delaye Arturo Becerra Leslie Orgel Antonio Lazcano |
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Institution: | (1) Facultad de Ciencias, UNAM, Apartado Postal 70-407, Cd. Universitaria, 04510 Mexico D.F., México;(2) Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA |
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Abstract: | Methionine sulfoxide reductases, enzymes that reverse the oxidation of methionine residues, have been described in a wide
range of species. The reduction of the diastereoisomers of oxidized methionine is catalyzed by two different monomeric methionine
sulfoxide reductases (MsrA and MsrB) and is best understood as an evolutionary response to high levels of oxygen either in
the Earth’s atmosphere or possibly in more localized environments. Phylogenetic analyses of these proteins suggest that their
distribution is the outcome of a complex history including many paralogy and lateral gene transfer events.
Electronic Supplementary Material Electronic Supplementary material is available for this article at
and accessible for authorised users.
Reviewing Editor: Dr. Martin Kreitman] |
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Keywords: | Methionine sulfoxide reductases Lateral gene transfer Methionine oxidation |
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