Inhibition of aspartic proteinases by propart peptides of human procathepsin D and chicken pepsinogen |
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| Authors: | M Fusek M Mares J Vágner Z Voburka M Baudys |
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| Affiliation: | Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Prague. |
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| Abstract: | ![]()
Two propart peptides of aspartic proteinases, the propart peptide of chicken pepsin and human cathepsin D, respectively, were investigated from the point of view of their inhibitory activity for a set of aspartic proteinases. These peptides display a very broad inhibitory spectrum. The strongest inhibition was observed for pepsin A-like proteinases where propart peptides can be used as titrants of active enzymes. |
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