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Synthesis and antimycobacterial activity of capuramycin analogues. Part 1: substitution of the azepan-2-one moiety of capuramycin |
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| Authors: | Hotoda Hitoshi Furukawa Miyuki Daigo Makiko Murayama Kazuhiro Kaneko Masakatsu Muramatsu Yasunori Ishii Michiko Miyazawa Miyakoshi Shun-ichi Takatsu Toshio Inukai Masatoshi Kakuta Masayo Abe Tomomi Harasaki Tamako Fukuoka Takashi Utsui Yukio Ohya Satoshi |
| Affiliation: | Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan. hotoda@hq.sankyo.co.jp |
| Abstract: |  Capuramycin analogues with a variety of substituents in place of the azepan-2-one moiety were synthesized from A-500359E and were tested for their translocase I inhibitory activity and in vitro antimycobacterial activity. Phenyl-type moieties were found to be effective substituents for capuramycin analogues. |
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