Evaluation of Antioxidant,Anticholinesterase, and Antidiabetic Potential of Dry Leaves and Stems in Tamarix aphylla Growing Wild in Tunisia |
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| Authors: | Adel Mahfoudhi Clara Grosso Rui F Gonçalves Eltaief Khelifi Saoussen Hammami Sami Achour Malika Trabelsi‐Ayadi Patrícia Valentão Paula B Andrade Zine Mighri |
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| Institution: | 1. Research Unit of Applied Chemistry and Environment (UR13ES63), Faculty of Sciences of Monastir, Monastir, Tunisia;2. Faculty of Sciences of Bizerte, University of Carthage, Carthage, Tunisia;3. REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia da Universidade do Porto, Porto, Portugal;4. Laboratory of Microbial Ecology and Technology (LR05ES08), National Institute of Applied Sciences and Technology, Tunis, Tunisia;5. Laboratory of Bioressources, Integrative Biology and Valorization, (LR14ES06), Higher Institute of Biotechnology of Monastir, Monastir, Tunisia;6. Applications Laboratory of Chemical and Natural Resources and Environment (LR05ES09), Faculty of Sciences of Bizerte, Jarzouna, Tunisia |
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| Abstract: | Tamarix aphylla (L.) Karst . has a wide geographic distribution and was employed in traditional medicine as astringent, anti‐rheumatic and to treat fever. T. aphylla leaves and stems extracts were studied from both chemical and biological points of view to assess the antidiabetic, anticholinesterase and antioxidant potential of this species. The HPLC/Diode Array Detector (DAD) analysis showed the presence of 14 phenolic compounds (gallic, caffeic, p‐coumaric, ferulic and ellagic acids, kaempferol, quercetin, quercetin 3‐O‐galactoside and six flavonol derivatives). This is the first study reporting a comparative study of the biological activities of different extracts from T. aphylla. High activities were obtained against DPPH radical, superoxide anion radical ( ) and nitric oxide radical (?NO) in a concentration‐dependent manner, the most active extracts being the polar ones. T. aphylla also showed moderate protective effects against acetylcholinesterase, but no effects were observed against butyrylcholinesterase. Against α‐glucosidase the MeOH extracts displayed IC50 values from 8.41 to 24.81 μg/ml. |
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| Keywords: |
Tamarix aphylla
Phenolic composition Free radicals Anticholinesterase α ‐Glucosidase |
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