Chemical Constituents of the Rare Cliff Plant Oresitrophe rupifraga and Their Antineuroinflammatory Activity |
| |
| Authors: | Xi‐Ying Wu Juan Xiong Xin‐Hua Liu Jin‐Feng Hu |
| |
| Institution: | 1. Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai, P. R. China;2. +86‐21‐51980171;3. Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, P. R. China |
| |
| Abstract: | Four new ( 1 – 4 ) and thirteen known ( 5 – 17 ) compounds were isolated from a rare cliff plant, Oresitrophe rupifraga. Based on spectroscopic evidence, the new structures were established to be (2S,3R,4R)‐4‐(4‐methoxybenzyl)‐2‐(4‐methoxyphenyl)‐tetrahydrofuran‐3‐yl]methanol ( 1 ), (3α)‐23‐(acetyloxy)‐3‐hydroxyolean‐12‐en‐29‐oic acid ( 2 ), 3α,23‐(isopropylidenedioxy)olean‐12‐en‐29‐oic acid ( 3 , artifact of isolation), and (3β,15β)‐3‐hydroxycholest‐5‐en‐15‐yl β‐d ‐glucopyranoside ( 4 ), respectively. Among the isolates, compounds 1 , 4 , epieudesmin ( 7 ), and 1‐O‐(9Z,12Z,15Z‐octadecatrienoyl)glycerol ( 17 ) were found to show significant antineuroinflammatory effects by inhibiting the NO production in lipopolysaccharide (LPS)‐stimulated murine BV‐2 microglial cells, with IC50 values of 7.21, 9.39, 4.96, and 8.51 μm , respectively. |
| |
| Keywords: |
Oresitrophe rupifraga
Rare cliff plant Lignans Oleanane triterpenoids Cholestane glycoside Antineuroinflammation |
|
|
