Effects of Forced Running Exercise on Cognitive Function and Its Relation to Zinc Homeostasis-Related Gene Expression in Rat Hippocampus |
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Authors: | Hong Ni Chao Li Xing Feng Jian-nong Cen |
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Institution: | (1) Neurology Laboratory, The Children’s Hospital Affiliated to Soochow University, No.303, Jingde Road, 215003 Suzhou, People’s Republic of China |
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Abstract: | Voluntary exercise has been implicated to be beneficial for overall health and cognitive function in both clinical and experimental
studies, but little is presently known about forced physical exercise on cognition and underlying molecular mechanism. We
have used real-time RT-PCR to analyze gene expression in hippocampus, in the presence and absence of physical exercise, during
spatial learning of rats in the Morris water maze. Our results show distinct zinc homeostasis-related gene expression profiles
associated with learning and memory. Rats with physical exercise (EXP) showed a significant up-regulation of mRNA expression
of zinc transporter-2 (ZnT-2), ZnT-4, ZnT-5, ZnT-6, and ZnT-7, metallothionein-1 (MT-1)–MT-3, divalent cation transporter-1,
and Zrt-Irt-like proteins-7 in hippocampus when compared with control rats. In addition, spatial learning ability was improved
in EXP rats compared with that in control group. This study provides the first comparative view of zinc homeostasis-related
gene expression in hippocampus following forced physical exercise. These results suggested that forced physical exercise may
provide a simple means to maintain brain function and promote learning capacity. Results of this study also suggest that exercise
mobilizes zinc homeostasis-related gene expression profiles that would be predicted to benefit brain plasticity processes. |
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