Multiple species of ornithine decarboxylase in rat tissues: Effects of dexamethasone |
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Authors: | James F Richards Kulgite Lit Roland Fuca Catherine Bourgeault |
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Institution: | Dept. of Biochemistry, University of British Columbia, Vancouver, B.C., Canada V6T 1W5 |
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Abstract: | Several species of ornithine decarboxylase were separated by chromatography of rat thymus and kidney extracts on DEAE-Sepharose CL-6B. One major and one minor species were absent from thymus of rats two hours after hormone treatment but otherwise, the elution profile was identical to thymus from control animals. The elution patterns of ODC activity in kidneys of rats treated 2.5 or 5 hours before sacrifice with dexamethasone differ from that of control kidney and from each other. Enzyme from kidneys early after hormone treatment is eluted earlier than enzyme from control tissue, while at 5 hours, the enzyme is eluted much later than in the control. This suggests that the hormone-induced activity is subsequently modified. |
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Keywords: | ODC ornithine decarboxylase DEX dexamethasone |
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