Novel Antifouling and Antimicrobial Compound from a Marine-Derived Fungus Ampelomyces sp. |
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Authors: | Theresa Fuk Ning Kwong Li Miao Xiancui Li Pei Yuan Qian |
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Institution: | (1) Department of Biology and Coastal Marine Laboratory, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Special Administrative Region, People's Republic of China;(2) Institute of Oceanology, Chinese Academy of Sciences (CAS), Qingdao, 266071, People's Republic of China |
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Abstract: | In this study, using a bioassay-guided isolation and purification procedure, we obtained 3-chloro-2,5-dihydroxybenzyl alcohol
from a marine-derived Ampelomyces species that effectively inhibited larval settlement of the tubeworm Hydroides elegans and of cyprids of the barnacle Balanus amphitrite. The inhibitive effect on larval settlement was nontoxic and the EC50 of 3-chloro-2,5-dihydroxybenzyl alcohol ranged from 3.19 μg ml−1 to 3.81 μg ml−1 while the LC50 was 266.68 μg ml−1 for B. amphitrite cyprids; EC50 ranged from 0.67 μg ml−1 to 0.78 μg ml−1, and LC50 was 2.64 μg ml−1 for competent larvae of H. elegans, indicating that inhibitive effect of this compound was nontoxic. At a concentration of 50 μg per disc, this compound showed
strong inhibitive effects on the growth of 13 out of 15 marine bacterial species tested in disc diffusion bioassay. Overall,
the high inhibitory activities against bacteria and larval settlement as well as the non- or low-toxic nature of this compound
to the barnacle and polychaete larvae suggest this compound could be a potent antifoulant and/or antibiotic. |
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Keywords: | Ampelomyces antifouling agent antimicrobial agent 3-chloro-2 5-dihydroxybenzyl alcohol |
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