Transfer factor in the treatment of a case of chronic mucocutaneous candidiasis |
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| Authors: | M L Schulking W H Adler W A Altemeier E M Ayoub |
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| Affiliation: | 1. Department of Environmental Health, Korea National Open University, Seoul, South Korea;2. Asian Citizen''s Center for Environment and Health, Seoul, South Korea;3. School of Public Health, Seoul National University, Seoul, South Korea;4. Department of Pediatrics, Chonnam National University Hospital, Gwangju, South Korea;5. Department of Pulmonary and Critical Care Medicine, Asan Medical Center, Univ. of Ulsan College of Medicine, Seoul, South Korea;6. Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea;7. Department of Occupational and Environmental Medicine, Gachon University Gil Medical Center, Incheon, South Korea;8. Department of Occupational and Environmental Health, Graduate School of Public Health, Yonsei University, Seoul, South Korea;9. Department of Preventive Medicine, Yonsei University, College of Medicine, Seoul, South Korea;10. Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea |
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| Abstract: | ![]()
A girl with a severe case of chronic mucocutaneous candidiasis in whom a partial defect in cell-mediated immunity to C. albicans was demonstrated is described. Chemotherapy with anti-Candida agents afforded only temporary clinical improvement.Although her delayed hypersensitivity skin test response to C. albicans was consistently negative, her lymphocytes underwent blast transformation when cultured in the presence of C. albicans and other mitogens. The addition of exogenous transfer factor to the culture medium increased her lymphocyte blast transformation response to C. albicans. Because of these findings she was treated with transfer factor with the aim of restoring expression of cutaneous hypersensitivity to the antigen, and providing her with clinically significant immunity to the antigen. Following a course of repeated injections of transfer factor given in conjunction with a short course of intravenous amphotericin B, her infection cleared and she has had no recurrence of infection for at least 6 months. |
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