Genome‐wide association study identifies genomic regions of association for cruciate ligament rupture in Newfoundland dogs |
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| Authors: | A. E. G. Baird S. D. Carter J. F. Innes W. Ollier A. Short |
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| Affiliation: | 1. Department of Infection Biology, Institute of Infection and Global Health, School of Veterinary Science, University of Liverpool, , Liverpool, L3 5RF UK;2. CIGMR (Centre for Integrated Genomic Medical Research), Faculty of Medical and Human Sciences Manchester University, , Manchester, M13 9PT UK;3. Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, , Liverpool, CH64 7TE UK |
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| Abstract: | ![]()
Cranial cruciate ligament rupture (CCLR) is the most common cause of pelvic limb lameness in dogs. To investigate the genetic basis of canine CCLR, we conducted a genome‐wide association study using a canine SNP array in Newfoundland pedigree dogs with and without CCLR (n = 96). We identified three main chromosomal regions of CCLR association (on chromosomes 1, 3 and 33). Each of these regions was confirmed by Sequenom genotyping in a further cohort of Newfoundlands (n = 271). The results, particularly SNPs identified in the SORCS2 and SEMA5B genes, suggest that there may be neurological pathways involved in susceptibility to canine CCLR. |
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| Keywords: | cranial cruciate ligament rupture Newfoundlands population stratification |
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