The IgG2a antibody response to thyroglobulin is linked to the Igh locus in mouse |
| |
| Authors: | Rudolf C Kuppers Leonardo D Epstein Ingrid M Outschoorn Noel R Rose |
| |
| Institution: | (1) Department of Immunology and Infectious Disease, The Johns Hopkins School of Hygiene and Public Health, 615 N. Wolfe St., 21205 Baltimore, MD, USA;(2) Department of Biostatistics, The Johns Hopkins School of Hygiene and Public Health, 615 N. Wolfe St., 21205 Baltimore, MD, USA;(3) Centro Nacional de Biologia Celular y Retrovirus, Instituto Carlos III, Majadahonda, 28220 Madrid, Spain;(4) SAIC, 5340 Spectrum DR., Suite N, Frederick, 21701-7337, MD, USA |
| |
| Abstract: | The IgG-subclass usage by several strains of mice in the response to immunization with mouse thyroglobulin (mTg) was examined in the experimental autoimmune thyroiditis model. While the subclass usage by most mouse strains was similar, the Ighb allotype-bearing mice consistently produced lower IgG2a levels to mTg. Using CBA-Igh
b
congenic and recombinant inbred strains of mice, the lower level of IgG2a in the Ighb mouse was mapped to the Igh locus. The regulation of IgG2a appeared to be cis controlled, as the CBA x C57BL/6F1 mouse also produced reduced IgG2a of the Ighb (B6) allotype but not Ighj (CBA) allotype. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
