Hybrid molecules based on fullerene C60 and 5Z,9Z-dienoic acids: Synthesis and cytotoxic activity |
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| Institution: | 1. Faculty of Science and Technology, Inter American University of Puerto Rico, Metropolitan Campus, PO Box 191293, San Juan, PR 00919, United States;2. Department of Chemistry, University of Puerto Rico, Rio Piedras Campus, PO Box 23346, San Juan, PR 00931-3346, United States;3. School of Environmental Affairs, Universidad Metropolitana, PO Box 21150, San Juan, PR 00928, United States;4. Department of Microbiology and Immunology, Universidad Central del Caribe School of Medicine, PO Box 60327, Bayamón, PR 00960, United States;1. Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan;2. Medicinal Mycology Research Center, Chiba University, Chiba 260-8763, Japan;3. Western Australian Museum, Locked Bag 49, Welshpool DC, WA 6986, Australia;1. Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan;2. Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan;1. State Key Laboratory Cultivation Base for Nonmetal Composites and Functional Materials, Southwest University of Science and Technology, Mianyang 621010, China;2. Department of Chemistry, School of Materials Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China |
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| Abstract: | The present research project details synthesis of new hybrid methanofullerenes based on acetylene and triazole esters of malonic acid containing 5Z,9Z-dienoic acids and fullerene C60 under Bingel-Hirsch conditions, including study of the cytotoxic activity with respect to Jurkat, K562, U937 and HL60 tumor cell lines. Hybrid methanofullerenes containing acetylenic fragments, unlike triazole substituents, were found to exhibit higher cytotoxicity, but are characterized by lower selectivity of action in relation to healthy cells. |
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| Keywords: | [60]Fullerene 5Z 9Z-dienoic acid 1 2 3-triazole Bingel-Hirsch reaction Methanofullerene |
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