Cromoglycate Induces a Rebound Effect on Blood/Milk Permeability in Subclinical Mastitis |
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Authors: | Pyörälä S Manila T Sandholm M |
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Institution: | 120.The Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Satu Pyörälä, SF-04840, Hautjärvi, Helsinki, Finland ; |
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Abstract: | Chronic subclinical mastitis represents a vicious cycle of constant tissue irritation by bacteria and inflammatory response of the host. Antibiotics have proven relatively inefficient in eliminating chronic mastitic infections. The use of anti-inflammatory agents in mastitis is controversial. Theoretically, the inflammation should not be suppressed as this is a host defence mechanism of the body. However, because it is uncertain whether the infection or chronic inflammation causes more harm to the tissue, there have been efforts to use anti-inflammatory agents such as glucocorticoids and antipyretic analgetics. The problem is that there is insufficient evidence as to which inflammatory mediators (histamine, kinins, prostaglandins, leukotrienes, PAF, interleukin-1 etc.) alone or in combination are important in mastitis. |
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