Anti-inflammatory principles from Lindera aggregata |
| |
| Affiliation: | 1. Experimental Research Center, China Academy of Chinese Medical Science, Beijing, China;2. Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Science, Beijing, China;3. Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, China;4. Beijing University of Chinese Medicine, Beijing, China;5. Department of Pathology, The Third People''s Hospital of Zhengzhou, Henan, China;6. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Science, Beijing, China;7. Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, China |
| |
| Abstract: | Four new sesquiterpenes (1–4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC50 values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively. |
| |
| Keywords: | Sesquiterpene Alkaloid Benzenoid glycoside Anti-inflammatory Superoxide anion generation Elastase release |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
