Hepatitis C virus experimental model systems and antiviral drug research |
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| Authors: | Susan L Uprichard |
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| Institution: | Department of Medicine, Section of Hepatology and Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA. |
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| Abstract: | An estimated 130 million people worldwide are chronically infected with hepatitis C virus (HCV) making it a leading cause of liver disease worldwide. Because the currently available therapy of pegylated interferon-alpha and ribavirin is only effective in a subset of patients, the development of new HCV antivirals is a healtheare imperative. This review discusses the experimental models available for HCV antiviral drug research, reeent advanees in HCV antiviral drug development, as well as active research being pursued to facilitate development of new HCV-speeifie therapeutics. |
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| Keywords: | Hepatitis C virus Chronic liver disease Experimental model systems High throughput screening Drug targets |
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