Trapping a folding intermediate of the alpha-helix: stabilization of the pi-helix |
| |
Authors: | Chapman Ross Kulp John L Patgiri Anupam Kallenbach Neville R Bracken Clay Arora Paramjit S |
| |
Affiliation: | Department of Chemistry, New York University, New York, New York 10003, USA. |
| |
Abstract: | We report the design, synthesis, and characterization of a short peptide trapped in a pi-helix configuration. This high-energy conformation was nucleated by a preorganized pi-turn, which was obtained by replacing an N-terminal intramolecular main chain i and i + 5 hydrogen bond with a carbon-carbon bond. Our studies highlight the nucleation parameter as a key factor contributing to the relative instability of the pi-helix and allow us to estimate fundamental helix-coil transition parameters for this conformation. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|