Acid-sensing ion channel 3 mediates peripheral anti-hyperalgesia effects of acupuncture in mice inflammatory pain期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Acid-sensing ion channel 3 mediates peripheral anti-hyperalgesia effects of acupuncture in mice inflammatory pain

Authors:	Wei-Hsin Chen Ching-Liang Hsieh Chun-Ping Huang Tzu-Jou Lin Jason TC Tzen Tin-Yun Ho Yi-Wen Lin

Affiliation:	(1) College of Agriculture and Natural Resources, Graduate Institute of Biotechnology, National Chung Hsing University, Taichung, Taiwan;(2) College of Chinese Medicine, Graduate Institute of Acupuncture Science and Acupuncture Research Center, China Medical University, Taichung, Taiwan;(3) College of Life Sciences, Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan;(4) College of Public Health, Department of Occupational Safety and Health, China Medical University, Taichung, Taiwan;(5) College of Chinese Medicine, School of Chinese Medicine, China Medical University, Taichung, Taiwan

Abstract:	Background Peripheral tissue inflammation initiates hyperalgesia accompanied by tissue acidosis, nociceptor activation, and inflammation mediators. Recent studies have suggested a significantly increased expression of acid-sensing ion channel 3 (ASIC3) in both carrageenan- and complete Freund's adjuvant (CFA)-induced inflammation. This study tested the hypothesis that acupuncture is curative for mechanical hyperalgesia induced by peripheral inflammation.

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