Accumulation of major histocompatibility complex class II+CD11c− non‐lymphoid cells in the spleen during infection with Plasmodium yoelii is lymphocyte‐dependent |
| |
Authors: | Rika Kamei Mana Miyakoda Takahiko Tamura Daisuke Kimura Kiri Honma Kazumi Kimura Katsuyuki Yui |
| |
Institution: | 1. Division of Immunology, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, , 1‐12‐4, Sakamoto, Nagasaki 852‐8523, Japan;2. Global COE Program, Nagasaki University, , 1‐12‐4, Sakamoto, Nagasaki 852‐8523, Japan |
| |
Abstract: | The spleen is the main organ for immune defense during infection with Plasmodium parasites and splenomegaly is one of the major symptoms of such infections. Using a rodent model of Plasmodium yoelii infection, MHC class II+CD11c? non‐T, non‐B cells in the spleen were characterized. Although the proportion of conventional dendritic cells was reduced, that of MHC II+CD11c? non‐T, non‐B cells increased during the course of infection. The increase in this subpopulation was dependent on the presence of lymphocytes. Experiments using Rag‐2?/? mice with adoptively transferred normal spleen cells indicated that these cells were non‐lymphoid cells; however, their accumulation in the spleen during infection with P. yoelii depended on lymphocytes. Functionally, these MHC II+CD11c? non‐T, non‐B cells were able to produce the proinflammatory cytokines alpha tumor necrosis factor and interleukin‐6 in response to infected red blood cells, but had only a limited ability to activate antigen‐specific CD4+ T cells. This study revealed a novel interaction between MHC II+CD11c? non‐lymphoid cells and lymphoid cells in the accumulations of these non‐lymphoid cells in the spleen during infection with P. yoelii. |
| |
Keywords: | inflammation lymphocytes major histocompatibility complex malaria |
|
|