Molecular epidemiology of Coxsackievirus A16 strains isolated from children in Yamagata,Japan between 1988 and 2011 |
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| Authors: | Katsumi Mizuta Chieko Abiko Yoko Aoki Tatsuya Ikeda Yoko Matsuzaki Seiji Hongo Tsutomu Itagaki Noriko Katsushima Akira Ohmi Hidekazu Nishimura Tadayuki Ahiko |
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| Institution: | 1. Department of Microbiology, Yamagata Prefectural Institute of Public Health, , Yamagata, 990‐0031 Japan;2. Department of Infectious Diseases, Yamagata University Faculty of Medicine, , Yamagata, 990‐9585 Japan;3. Yamanobe Pediatric Clinic, , Yamagata, 990‐0301 Japan;4. Katsushima Pediatric Clinic, , Yamagata, 990‐2461 Japan;5. Virus Research Center, Sendai Medical Center, , Sendai, 983‐8520 Japan |
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| Abstract: | To clarify the longitudinal molecular epidemiology of coxsackievirus A16, phylogenetic analysis based on the VP1 region of 220 isolates in Yamagata, Japan was performed. The resultant phylogenetic tree indicates that the Yamagata isolates and reference strains can be readily genotyped into three genogroups, and 0, 12 and 208 isolates belonged to the first, second, and third genogroups, respectively. The first genogroup includes only the prototype strain, the second strains that had disappeared by the end of the 20th century and the third comprises those that have been circulating since then in local communities, such as Yamagata. |
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| Keywords: | Coxsackievirus A16 molecular epidemiology genogroup phylogenetic analysis |
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