Long-term feeding effects of Catha edulis leaves on blood constituents in animals |
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Authors: | M Al-Habori M Al-Mamary |
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Institution: | aClinical Biochemistry Department, Faculty of Medicine and Health Sciences, University of Sana’a, P.O. Box 19065, Sana’a, Yemen bDepartment of Pharmacy, Faculty of Medicine and Health Sciences, University of Sana’a, Sana’a, Yemen |
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Abstract: | In this study, the long-term (6 months) biochemical effects of varying levels of Catha edulis leaves on the plasma concentration of glucose, triglycerides, cholesterol, HDL-cholesterol, total protein, albumin, uric acid, urea and creatinine were examined. Our results demonstrated a significant decrease in plasma cholesterol throughout the treatment period by all levels of C. edulis leaves tested. This significant decrease in plasma cholesterol was halved at the end of the treatment period and corresponded with a significant increase in plasma HDL-cholesterol and a significant decrease in plasma glucose and triglycerides concentrations. Moreover, C. edulis treatment increased plasma uric acid significantly, in a time-dependent manner with the higher concentrations (20% and 30%) of C. edulis leaves. Only plasma albumin was decreased significantly at the end of the treatment period, with no significant effect on plasma total protein. This also coincided with a significant, dose-dependent decrease in plasma urea at month 6, with no significant effect on plasma creatinine concentration. |
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Keywords: | Catha edulis Khat Biochemical parameters Lipid profile Uric acid |
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