Maturation by LctT Is Required for Biosynthesis of Full-Length Lantibiotic Lacticin 481 |
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| Authors: | Patricia Uguen, Thomas Hindr , Sandrine Didelot, Christel Marty, Dominique Haras, Jean-Paul Le Pennec, Karine Vall e-R hel, Alain Dufour |
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| Affiliation: | Patricia Uguen, Thomas Hindré, Sandrine Didelot, Christel Marty, Dominique Haras, Jean-Paul Le Pennec, Karine Vallée-Réhel, and Alain Dufour |
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| Abstract: | In lantibiotic lacticin 481 biosynthesis, LctT cleaves the precursor peptide and exports mature lantibiotic. Matrix-assisted laser desorption ionization-time of flight mass spectrometry revealed that a truncated form of lacticin 481 is produced in the absence of LctT or after cleavage site inactivation. Production of truncated lacticin 481 is 4-fold less efficient, and its specific activity is about 10-fold lower. |
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