Protective effect of magnesium supplementation on experimental 3-methyl cholantrene-induced fibrosarcoma and changes in tissue magnesium distribution during carcinogenesis in rats |
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| Authors: | Türkan Patiroğlu Gürses Şahin Olgun Kontaş Kazim Üzüm Recep Saraymen |
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| Institution: | 1. Medical Faculty, Departments of Pediatrics, Pathology, and Biochemistry, Erciyes University, Kayseri, Türkiye
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| Abstract: | In this study, we wanted to examine the effect of magnesium (Mg2+) supplementation on the experimental 3-methyl cholantrene (3-MC)-induced fibrosarcoma and alterations in (Mg2+) distribution in several tissues of the rats, during carcinogenesis. It was determined that serum and tissue (Mg2+) levels of the rats in (Mg2+)-supplemented diet group were higher than those of the rats in the (Mg2+)-nonsupplemented and control groups. The mean time of fibrosarcoma development for (Mg2+)-supplemented group was longer than (Mg2+)-nonsupplemented group (p<0.05). Symptoms of hypermagnesemia were not observed in any of the rats. These results suggests that dietary (Mg2+) supplementation may have a partial anticarcinogenic effect on experimental 3-MC-induced fibrosarcoma by prolongation of the latent period of carcinogenesis. |
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