Lipid peroxidation and neurodegenerative disease |
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| Authors: | Reed Tanea T |
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| Affiliation: | Department of Chemistry, Eastern Kentucky University, Richmond, KY 40475, USA |
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| Abstract: | Lipid peroxidation is a complex process involving the interaction of oxygen-derived free radicals with polyunsaturated fatty acids, resulting in a variety of highly reactive electrophilic aldehydes. Since 1975, lipid peroxidation has been extensively studied in a variety of organisms. As neurodegenerative diseases became better understood, research establishing a link between this form of oxidative damage, neurodegeneration, and disease has provided a wealth of knowledge to the scientific community. With the advent of proteomics in 1995, the identification of biomarkers for neurodegenerative disorders became of paramount importance to better understand disease pathogenesis and develop potential therapeutic strategies. This review focuses on the relationship between lipid peroxidation and neurodegenerative diseases. It also demonstrates how findings in current research support the common themes of altered energy metabolism and mitochondrial dysfunction in neurodegenerative disorders. |
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| Keywords: | Aβ, amyloid-β peptide ALDO1, aldolase AD, Alzheimer disease ALS, amyotrophic lateral sclerosis APP, amyloid precursor protein BDNF, brain-derived neurotrophic factor CK, creatine kinase CR1, carbonyl reductase CSF, cerebrospinal fluid DHA, docosahexanoic acid DHAP, dihydroxyacetone phosphate DRP-2, dihydropyrimidinase-related protein 2 EAD, early Alzheimer disease EF-Tu, elongation factor Tu eIF-α, initiation factor α ENO1, α-enolase ERK, extracellular signal-regulated kinase ETC, electron transport chain G3P, glyceraldehyde 3-phosphate GAPDH, glyceraldehyde-3-phosphate dehydrogenase GFAP, glial fibrillary acidic protein GS, glutamine synthetase HD, Huntington disease HNE, 4-hydroxy-2-nonenal HP, hippocampus HPLC, high-performance liquid chromatography HSP, heat shock protein IPL, inferior parietal lobule LAD, late stage Alzheimer disease LDH, lactate dehydrogenase B MCI, mild cognitive impairment MDH, malate dehydrogenase MEK, mitogen-activated protein kinase kinase MPTP, mitochondrial permeability transition pore NAD+, nicotinamide adenine dinucleotide (oxidized) NF-L, neurofilament light chain NF-M, neurofilament medium chain NFT, neurofibrillary tangle NMDA, N-methyl- smallcaps" >d-aspartic acid PCAD, preclinical Alzheimer disease PD, Parkinson disease PET, positron emission tomography PGK, phosphoglycerate kinase PK, pyruvate kinase PRX, peroxiredoxin ROS, reactive oxygen species SOD, superoxide dismutase TCA, tricarboxylic acid TPA, tissue-type plasminogen activator TPI, triose phosphate isomerase UCHL1, ubiquitin carboxyterminal hydroxylase 1 VDAC1, voltage-dependent anion channel 1 |
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