Dichloro(6-aminoethylaminopurine)platinum(II) and its hydroxy analogues: Synthesis and preliminary evaluation |
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| Authors: | Janina Baranowska-Kortylewicz Edward J. Pavlik Walter T. Smith Robert C. Flanigan J.R. Van Nagell Dawn Ross Daniel E. Kenady |
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| Affiliation: | The Lexington Veterans Administration Medical Center and the Departments of Chemistry, Obstetrics and Gynecology, Biochemistry, Urology and Surgery, University of Kentucky, Lexington, Ky. 40536, U.S.A. |
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| Abstract: | ![]()
The synthesis, chemical characterization and functional evaluation are reported for dichloro(6-aminoethylaminopurine)platinum(II) and dichloro(6-hydroxyethylaminopurine)platinum(II) and dichloro(6-hydroxyethylamethylaminopurine)platinum(II) (i.e. Pt(6-AEAP), Pt(6-HEAP) and Pt(6-MHEAP) new complexes of platinum(II). Certain reaction conditions favored the formation of the tripurine platinum complex, but the monopurine complex could be obtained either by hydrolysis of the tripurine or by reacting at reduced temperature and concentration. Although neither compound was as effective as cis-diamminedichloroplatinum(II) (i.e. DDP) at reducing tumor cell viability or proliferation, both were associated with much less renal toxicity than DDP in the mouse kidney (i.e. Pt(6-AEAP):～20 × less; Pt(6-MHEAP): ～100 × less). |
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| Keywords: | Author to whom correspondence should be addressed. |
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