| 类器官及其应用的研究进展 |
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| 引用本文： | 李甜瑞,赵瑞波,张权,孔祥东.类器官及其应用的研究进展[J].生物化学与生物物理进展,2019,46(8):737-750. |
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| 作者姓名： | 李甜瑞 赵瑞波 张权 孔祥东 |
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| 作者单位： | 浙江理工大学材料与纺织学院，杭州 310018；浙江-毛里求斯生物医用材料与组织工程联合研究中心，杭州 310018；浙江理工大学生命科学与医药学院，杭州 310018,浙江理工大学材料与纺织学院，杭州 310018；浙江-毛里求斯生物医用材料与组织工程联合研究中心，杭州 310018,浙江理工大学材料与纺织学院，杭州 310018；浙江-毛里求斯生物医用材料与组织工程联合研究中心，杭州 310018,浙江理工大学材料与纺织学院，杭州 310018；浙江-毛里求斯生物医用材料与组织工程联合研究中心，杭州 310018 |
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| 基金项目： | 国家自然科学基金（51672250），浙江省自然科学基金（LQ19E020010）和浙江省“一带一路”国际科技合作项目（2019C04020）资助. |
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| 摘 要： | 类器官弥补了传统研究中细胞简单模型与动物复杂模型的不足,为生命体关键功能研究提供了重要实验基础,已成为当前研究热点,并在疾病机理研究、药物筛选、再生医学、生物材料评价等方面具有重大理论意义和应用前景.本文对近10年类器官研究进行了综述,阐述出类器官研究的发展历程和研究现状,重点综述了类器官的主要研究领域,并解析类器官研究中存在的关键科学问题,为类器官在生物医药、再生医学和疾病精准治疗领域的研究和应用提供新思路.
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| 关 键 词： | 类器官 药物筛选 再生医学 血管化 生物材料 |
| 收稿时间： | 2019/3/8 0:00:00 |
| 修稿时间： | 2019/6/11 0:00:00 |
Progress in The Research of Organoids and Applications |
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| LI Tian-Rui,ZHAO Rui-Bo,ZHANG Quan and KONG Xiang-Dong.Progress in The Research of Organoids and Applications[J].Progress In Biochemistry and Biophysics,2019,46(8):737-750. |
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| Authors: | LI Tian-Rui ZHAO Rui-Bo ZHANG Quan and KONG Xiang-Dong |
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| Institution: | College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China; Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Hangzhou 310018, China; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China,College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China; Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Hangzhou 310018, China,College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China; Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Hangzhou 310018, China,College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China; Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Hangzhou 310018, China |
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| Abstract: | Organoid can make up for the deficiency of cell models and animal models commonly used in traditional research. And it also provides an important experimental basis for the study of key functional studies of living organisms. At the present stage, organoid model has become a hot research field and is of great significance in disease mechanism research, drug screening, regenerative medicine, and biomedical material evaluation. In this paper, the research of organoids in the past 10 years is reviewed. It summarizes the development history and research status of organoid research, and also focuses on the main research fields of organoids. In addition, this paper mainly analyzes the key scientific issues in the study of organoids and propose ideas for organoid in biomedicine, regenerative medicine and precise treatment of diseases. |
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| Keywords: | organoids drug screening regenerative medicine vascularization biomaterial |
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