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Viruses detected in cells explanted into tissue culture from naturally occurring malignant lymphoma in rhesus monkeys
Authors:JaRue S. Manning  Richard A. Griesemer
Affiliation:(1) Department of Bacteriology and California Primate Research Center, University of California, 95616 Davis, California, USA;(2) National Cancer Institute, National Institutes of Health, 20014 Bethesda, Maryland, USA
Abstract:
During a 4-year period 43 cases of spontaneous lymphoma occurred in macaques at the California Primate Research Center. In an attempt to determine if there might be a common viral etiology to the outbreak, lymphoma tissues from 10 rhesus monkeys were explanted into tissue culture and examined for the presence of virus. Electron microscopic studies of the cultured lymphoma cells revealed viruses morphologically characteristics of adenovirus, reovirus, foamy virus, and herpesvirus. Cell-free filtrates from tissue cultures possessing the latter three viruses produced cytopathology in virus-free indicator cells. Virus particles typical of the explant culture were demonstrable in the infected indicator cells. Type-C RNA tumor virus particles were not observed electron microscopically in any of the lymphoma tissues or lymphoma cell cultures examined.
Keywords:
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