The prevalence of plasmid‐mediated quinolone resistance determinants among clinical isolates of ESBL or AmpC‐producing Escherichia coli from Chinese pediatric patients |
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| Authors: | Chenxi Han Yonghong Yang Minggui Wang Aihua Wang Quan Lu Xiwei Xu Chuanqing Wang Lan Liu Qiulian Deng Xuzhuang Shen |
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| Affiliation: | 1. Beijing Children's Hospital, Affiliated to Capital Medical University, Beijing, 100045;2. Division of Infectious Diseases, Huashan Hospital, Affiliated to Fudan University, Shanghai, 200040;3. Shanghai Children's Hospital, Affiliated to Shanghai Jiao Tong University, Shanghai, 200040;4. The Children's Hospital of Fudan University, Shanghai, 201102;5. Chongqing Children's Hospital Affiliated to Chongqing Medical University, Chongqing, 400014;6. Guangzhou Children's Hospital, Affiliated to Guangzhou Medical College, Guangzhou, 510120, China |
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| Abstract: | Three kinds of PMQR determinants (qnr genes, aac(6’)‐Ib‐cr, and qepA) have been discovered and shown to be widely distributed among clinical isolates. To characterize the prevalence of PMQR determinants in ESBL or AmpC‐producing E. coli clinical isolates in Chinese children, a total of 292 ESBL or AmpC‐producing E. coli clinical isolates collected from five children's hospitals in China from 2005 to 2006 were screened for PMQR determinants by PCR. Twenty (6.8%) of the 292 isolates were positive for PMQR determinants. A total of 12 (4.1%) isolates were positive for qnr genes, comprising three positive for qnrA (1.0%), three for qnrB (1.0%), and six for qnrS (2.1%). Twenty‐four (8.2%) isolates were positive for aac(6’)‐Ib, of which 10 (3.4% of 292) had the –cr variant. There was no qepA gene detected in the isolates. Conjugation revealed that qnr, aac(6’)‐Ib‐cr, and ESBL‐encoding genes were transferred together. |
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| Keywords: | ESBL or AmpC‐producing Escherichia coli Pediatrics PMQR quinolone resistance |
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