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Synthesis and BZR affinity of pyrazolo[1,5-a]pyrimidine derivatives. Part 1: study of the structural features for BZR recognition |
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| Authors: | Selleri S Bruni F Costagli C Costanzo A Guerrini G Ciciani G Costa B Martini C |
| Institution: | a Department of Pharmaceutical Sciences, University of Firenze, Via G. Capponi 9, 50121, Florence, Italy b Department of Psychiatry, Neurobiology, Pharmacology and Biotechnologies, Via Bonanno 6, 56126, Pisa, Italy |
| Abstract: | Examination of the pharmacophoric points of the pyrazolo1,5-a]pyrimidine derivatives, ligands for BZR, previously published led us to the design of a novel class of 3,6-diaryl-4,7-dihydro-pyrazolo1,5-a]pyrimidin-7-ones and to determine the groups involved in the BZR recognition. |
| Keywords: | Benzodiazepine receptor (BZR) binding studies pyrazolo[1 5-a]pyrimidine derivatives structure–affinity relationship (SAFIR) partial agonists |
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