脐带血来源干细胞神经分化的研究进展

中枢神经系统损伤后的自身修复能力有限，因而研究者致力于寻找一种合适的细胞进行移植以代替受损的神经细胞修复神经损伤。近年来的研究表明，脐带血干细胞能够在体外诱导条件下向神经样细胞分化，并在动物体内实验中促进神经损伤的恢复，有可能作为一种有效的细胞资源，应用于人类中枢神经系统疾病的细胞替代治疗以及神经保护与支持。

Progress in neural Differentiation of Umbilical Cord Blood - derived Stem Cells

The ability of repair and regeneration of central nervous system (CNS) is limited. So many researchers applied themselves to search a valuable cell resource for treating severe diseases of the CNS. Several studies from different laboratories have recently reported that stem cells derived from human umbilical cord blood under certain in vitro conditions can manifest neural features that resemble features of neural-derived cells. In vivo transplantation studies have shown that these stem cells persistently engraft in the CNS, some engrafted cells acquire the characteristics of neurons and glia, and improve functional recovery after central nervous system injury. The existence of stem/progenitor cells with previously unappreciated proliferation and differentiation potential in umbilical cord blood raise the possibility that cord blood may provide an efficient source of cells differentiating into the neural lineage, with a potential to be employed in the therapy of human CNS diseases. The achievement and focuses on the mechanisms and modulation of induction of differentiation and in vitro and in vivo studies in this field was reviewed.