Inhibition of brain ST8SiaIII sialyltransferase leads to impairment of procedural memory in mice |
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| Authors: | Adriana R Rinflerch Valeria L Burgos Marcelo Ielpi Marcos Ojea Quintana Alejandra M Hidalgo Monica Loresi Pablo F Argibay |
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| Institution: | Instituto de Ciencias Básicas y Medicina Experimental – Hospital Italiano de Buenos Aires, Potosí 4240 8th floor, C1199ACL, Ciudad Autónoma de Buenos Aires, Argentina |
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| Abstract: | Several glycoproteins in mammalian brains contain α2,8-linked disialic acid residues. We previously showed a constant expression of disialic acid (DiSia) in the hippocampus, olfactory bulb and cortex, and a gradual decrease of expression in the cerebellum from neonatal to senile mice. Previous publications indicate that neurite extension of neuroblastoma-derived Neuro2A cells is inhibited in the presence of DiSia antibody. Based on this, we treated Neuro2A cell cultures with RNA interference for ST8SiaIII mRNA, the enzyme responsible for DiSia formation. We observed that neurite extension was inhibited by this treatment. |
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| Keywords: | Cerebellum Disialic acid ST8SiaIII Sialyltransferase T-maze |
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