Alzheimer disease periventricular white matter lesions exhibit specific proteomic profile alterations |
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| Authors: | Eduardo M. Castañ o,Chera L. Maarouf,Terence Wu,Maria Celeste Leal,Charisse M. Whiteside,Lih-Fen Lue,Tyler A. Kokjohn,Marwan N. Sabbagh,Thomas G. Beach,Alex E. Roher |
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| Affiliation: | 1. Fundación Instituto Leloir and Instituto de Investigaciones Bioquímicas de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Patricias Argentinas 435, Buenos Aires C1405BWE, Argentina;2. The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, 10515 W. Santa Fe Dr., Sun City, AZ 85351, USA;3. The W.M. Keck Laboratory, Yale University, 300 George Street, Box 201, New Haven, CT 06511, USA;4. Laboratory of Neuroregeneration, Banner Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA;5. Department of Microbiology, Midwestern University School of Medicine, 19389 N. 59th Ave., Glendale, AZ 85308, USA;6. Roberts Clinical Center, Banner Sun Health Research Institute, 10515 W. Santa Fe Dr., Sun City, AZ 85351, USA;g Harold Civin Laboratory of Neuropathology, Banner Sun Health Research Institute, 10515 W. Santa Fe Dr., Sun City, AZ 85351, USA |
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| Abstract: | ![]()
The white matter (WM) represents approximately half the cerebrum volume and is profoundly affected in Alzheimer’s disease (AD). However, both the WM responses to AD as well as potential influences of this compartment to dementia pathogenesis remain comparatively neglected. Neuroimaging studies have revealed WM alterations are commonly associated with AD and renewed interest in examining the pathologic basis and importance of these changes. |
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| Keywords: | 2D-DIGE, 2-dimensional difference gel electrophoresis AD, Alzheimer&rsquo s disease ANXA1, annexin A1 AP, amyloid plaques ApoE, apolipoprotein E CAA, cerebral amyloid angiopathy CALM, calmodulin CRMP-2, collapsin response mediator protein-2 DTI, diffusion tenor imaging FSCN1, fascin 1 GFAP, glial fibrillary acidic protein GM, gray matter H& E, hematoxylin and eosin INA, α-internexin MCI, mild cognitive impairment MRI, magnetic resonance imaging NDC, non-demented control NFT, neurofibrillary tangles OD, optical density PBS, phosphate buffered saline PBS-T, phosphate buffered saline containing 0.3% Tween20 PVWM, periventricular white matter RT, room temperature TFA, trifluoroacetic acid TMS, thymosine TPM, tropomyosin WM, white matter WMH, white matter hyperintensities WMP, white matter pathology WMR, white matter rarefaction VDAC1, voltage-dependent anion channel 1 VIM, vimentin |
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