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The patients with clinically isolated syndrome and relapsing remitting multiple sclerosis show different levels of advanced protein oxidation products and total thiol content in plasma and CSF |
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| Authors: | Srdjan Ljubisavljevic Ivana Stojanovic Slobodan Vojinovic Dragan Stojanov Svetlana Stojanovic Tatjana Cvetkovic Dejan Savic Dusica Pavlovic |
| Institution: | 1. Clinic of Neurology, Clinical Center Nis, Bul. Dr Zorana Djindjica 48, 18000 Nis, Serbia;2. Institute for Pathophysiology, Faculty of Medicine, University of Nis, Bul. Dr Zorana Djindjica 81, 18000 Nis, Serbia;3. Institute for Biochemistry, Faculty of Medicine, University of Nis, Bul. Dr Zorana Djindjica 81, 18000 Nis, Serbia;4. Center for Radiology, Clinical Center Nis, Bul. Dr Zorana Djindjica 48, 18000 Nis, Serbia |
| Abstract: | Advanced oxidation protein products (AOPP) and total thiol (SH) groups levels in plasma and CSF were studied in a cohort of 50 clinically isolated syndrome (CIS) and 57 relapsing remittent multiple sclerosis (RRMS) patients related to 20 control group (CG) patients’ values. The obtained results were compared regarding patients demographic, biochemical, clinical (EDSS) and MRI features (total T2 weighted lesions number and Gd enhancement lesion volume). |
| Keywords: | AOPP SH groups EDSS MRI Clinically isolated syndrome Relapsing remitting multiple sclerosis |
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