miR‐346 promotes migration and invasion of nasopharyngeal carcinoma cells via targeting BRMS1 |
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| Authors: | Hong‐ling Yan Li Li Shu‐juan Li Hai‐sheng Zhang Wei Xu |
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| Institution: | 1. Department of Otorhinolaryngology, Tangshan Maternity and Child Health Care Hospital, Tangshan, People's Republic of China;2. Department of Radiotherapy, Shanghai Armed Police Hospital, Shanghai, People's Republic of China;3. Department of Neurosurgery, Huashan Hospital, Fudan University of Medicine, Shanghai, People's Republic of China |
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| Abstract: | The aim of this study is to determine the expression and roles of miR‐346 in nasopharyngeal carcinoma (NPC). We showed that miR‐346 was upregulated in NPC tissues compared with adjacent non‐tumorous nasopharyngeal tissues. Inhibition of miR‐346 significantly attenuated the migration and invasion of NPC cells. Luciferase reporter assay showed that miR‐346 targeted the 3′‐untranslated region (3′‐UTR) of breast cancer metastasis suppressor 1 (BRMS1). Overexpression of miR‐346 suppressed the endogenous expression of BRMS1 in NPC cells. There was a significant negative correlation between miR‐346 and BRMS1 protein expression in NPC tissues (r = ?0.372, P = 0.008). Rescue experiments demonstrated that overexpression of BRMS1 lacking the 3′‐UTR impaired the invasiveness of NPC cells transfected with miR‐346 mimic. Taken together, miR‐346 shows the ability to promote the migration and invasion of nasopharyngeal cancer cells via targeting BRMS1 and represents a potential therapeutic target for NPC. |
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| Keywords: | invasion microRNA migration nasopharyngeal carcinoma target gene |
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