抗氧化剂与自由基清除剂对硒性白内障形成的影响

本文观察了8种化合物(抗氧化剂及自由基清除剂)对大鼠亚硒酸钠性白内障的影响。实验分为正常对照组,亚硒酸钠组及药物对抗组。亚硒酸钠组系给13日龄大鼠皮下注射亚硒酸钠(6μmoles/kg体重),间日一次,逐次递增1μmole/kg体重,连续5次,药物对抗组则同时腹腔注射抗氧化剂或自由基清除剂,每日观察并记录白内障的发生频率及程度,实验表明,一些抗氧化剂及自由基清除剂能够有效的对抗亚硒酸钠性白内障的发生发展,其中AC1、AC3及AC3的效果尤为明显。本文的结果为探讨白内障形成机理及防治提供了实验依据。

Effects of Antioxidants or Free Free Radical Scavengers on Cataract Formation Induced by Selenium

The effects of 8 compounds on cataractogenesis induced by selenium was investegated.Starting from the 13th day after birth, suckling Wistar rats received subcutaneous injections of either Na2SeO3 alone or selenium plus one of the 8 compounds injected intraperitoneally at the same time every other day. The frequency and severity of cataracts were examined and recorded daily. Eight compounds were found to be effective on preventing selenium-induced caratact(%protectcon), AC1 100%(1.1×10-4mmole/lOg b.w), AC2 100%(4. 5×10-3mmole/10g b.w),GSH100% (4×10-2mmole/10g b.w) ,DMSO100%(1mmle/10g b.w) ,mannitol 100%(1.1×10-1), AC3 94%(2×10-2mmole/10g b.w), VE 86%(1×10-3), and VC 62%(7×10-2). Among these antioxidants or radical scavengers, ACl, AC2, and AC3 showed no side effect on rats.