Amyloid properties of titin |
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| Authors: | E I Yakupova I M Vikhlyantsev M Y Lobanov O V Galzitskaya A G Bobylev |
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| Institution: | 1.Institute of Theoretical and Experimental Biophysics,Russian Academy of Sciences,Pushchino, Moscow Region,Russia;2.Pushchino State Institute of Natural Sciences,Pushchino, Moscow Region,Russia;3.Institute of Protein Research,Russian Academy of Sciences,Pushchino, Moscow Region,Russia |
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| Abstract: | This review considers data on structural and functional features of titin, on the role of this protein in determination of mechanical properties of sarcomeres, and on specific features of regulation of the stiffness and elasticity of its molecules, amyloid aggregation of this protein in vitro, and possibilities of formation of intramolecular amyloid structure in vivo. Molecular mechanisms are described of protection of titin against aggregation in muscle cells. Based on the data analysis, it is supposed that titin and the formed by it elastic filaments have features of amyloid. |
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