| 流感病毒神经氨酸酶抑制剂药物耐药现状及机制研究进展 |
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| 引用本文： | 黄兰,周剑芳,韦红,舒跃龙.流感病毒神经氨酸酶抑制剂药物耐药现状及机制研究进展[J].病毒学报,2012,28(5):572-576. |
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| 作者姓名： | 黄兰 周剑芳 韦红 舒跃龙 |
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| 作者单位： | 中国疾病预防控制中心病毒病预防控制所世界卫生组织全球流感参比和研究合作中心病毒基因工程国家重点实验室,北京102206;重庆医科大学附属儿童医院,重庆400014;中国疾病预防控制中心病毒病预防控制所世界卫生组织全球流感参比和研究合作中心病毒基因工程国家重点实验室,北京,102206;重庆医科大学附属儿童医院,重庆,400014 |
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| 摘 要： | 流感病毒可引起急性呼吸道传染病,严重危害人们的身体健康。神经氨酸酶抑制剂(NAI)是以神经氨酸酶为靶点的药物,可以有效抑制甲型和乙型流感病毒复制,是目前流感预防和治疗的一线用药。然而由于NA或者HA的突变,导致病毒对该药耐药。不同亚型流感病毒对神经氨酸酶抑制剂的耐药情况也不同,不同的检测方法也对判断病毒是否耐药有影响。
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| 关 键 词： | 流感病毒 神经氨酸酶抑制剂 耐药突变 |
Neuraminidase Inhibitors Resistance in Influenza Viruses and the Related Mechanisms |
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| HUANG Lan,ZHOU Jian-fang,WEI Hong,SHU Yue-long.Neuraminidase Inhibitors Resistance in Influenza Viruses and the Related Mechanisms[J].Chinese Journal of Virology,2012,28(5):572-576. |
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| Authors: | HUANG Lan ZHOU Jian-fang WEI Hong SHU Yue-long |
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| Institution: | 1(1.World Health Organization Global Influenza Collaboration Centre for Reference and Research State Key Laboratory for Molecular Virology and Genetic Engineering Chinese Center for Disease Control and Prevention National Institute for Viral Disease Control and Prevention,Beijing 102206,China; 2.Children’s Hospital of Chongqing Medical University,Chongqing 400014,China) |
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| Abstract: | Influenza viruses are highly contagious for human population and result in acute respiratory infectious diseases ranging from mild to severe.Neuraminidase(NA) inhibitors(NAIs)(oseltamivir,zanamivir,peramivir and laninamivir),which target the NA glycoproteins of influenza A and B viruses are widely used in the prophylaxis and treatment of influenza virus infection.However,the substitutions of amino acids in NA or HA gene may lead to resistances to NAIs.NAI-resistance-related substitutions are typically specific to certain NA type or subtype.The sensitivity for NAI-resistance detection is affected by different assays used. |
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| Keywords: | Influenza virus Neuraminidase inhibitors Drug-resistant mutations |
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