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CoupTFI Interacts with Retinoic Acid Signaling during Cortical Development |
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| Authors: | Susan J. Harrison-Uy Julie A. Siegenthaler Andrea Faedo John L. R. Rubenstein Samuel J. Pleasure |
| Affiliation: | 1. Department of Neurology, University of California San Francisco, San Francisco, California, United States of America.; 2. Department of Psychiatry, University of California San Francisco, San Francisco, California, United States of America.; 3. Programs in Neuroscience and Developmental Biology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, California, United States of America.; University of Fukui, Japan, |
| Abstract: | We examined the role of the orphan nuclear hormone receptor CoupTFI in mediating cortical development downstream of meningeal retinoic acid signaling. CoupTFI is a regulator of cortical development known to collaborate with retinoic acid (RA) signaling in other systems. To examine the interaction of CoupTFI and cortical RA signaling we utilized Foxc1-mutant mice in which defects in meningeal development lead to alterations in cortical development due to a reduction of RA signaling. By analyzing CoupTFI−/−;Foxc1H/L double mutant mice we provide evidence that CoupTFI is required for RA rescue of the ventricular zone and the neurogenic phenotypes in Foxc1-mutants. We also found that overexpression of CoupTFI in Foxc1-mutants is sufficient to rescue the Foxc1-mutant cortical phenotype in part. These results suggest that CoupTFI collaborates with RA signaling to regulate both cortical ventricular zone progenitor cell behavior and cortical neurogenesis. |
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