Characterization of an Acid-Inducible Sulfatase in Salmonella enterica Serovar Typhimurium |
| |
| Authors: | Seema Das Swati Singh Michael McClelland Steven Forst Prasad Gyaneshwar |
| |
| Affiliation: | aDepartment of Biological Sciences, University of Wisconsin Milwaukee, Milwaukee, Wisconsin, USA;bDepartment of Pathology, University of California, Irvine, California, USA |
| |
| Abstract: | ![]()
Sulfatases of enteric bacteria can provide access to heavily sulfated mucosal glycans. In this study, we show that aslA (STM0084) of Salmonella enterica serovar Typhimurium LT2 encodes a sulfatase that requires mildly acidic pH for its expression and activity. AslA is not regulated by sulfur compounds or tyramine but requires the EnvZ-OmpR and PhoPQ regulatory systems, which play an important role in pathogenesis. |
| |
| Keywords: | |
|
|
