Bacterial Protein N-Glycosylation: New Perspectives and Applications |
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Authors: | Harald Nothaft Christine M Szymanski |
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Institution: | From the Alberta Glycomics Centre and Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada |
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Abstract: | Protein glycosylation is widespread throughout all three domains of life. Bacterial protein N-glycosylation and its application to engineering recombinant glycoproteins continue to be actively studied. Here, we focus on advances made in the last 2 years, including the characterization of novel bacterial N-glycosylation pathways, examination of pathway enzymes and evolution, biological roles of protein modification in the native host, and exploitation of the N-glycosylation pathways to create novel vaccines and diagnostics. |
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Keywords: | Campylobacter Evolution Glycoconjugate Glycosyltransferases Vaccines Glycoengineering HMW1C N-Linked Protein Glycosylation PglB Di-N-acetylbacillosamine |
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