Low Prevalence of Cfr-Mediated Linezolid Resistance among Methicillin-Resistant Staphylococcus aureus in a Spanish Hospital: Case Report on Linezolid Resistance Acquired during Linezolid Therapy |
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| Authors: | Josep M. Sierra Mariana Camoez Fe Tubau Oriol Gasch Miquel Pujol Rogelio Martin M. Angeles Domínguez |
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| Affiliation: | 1. Department of Microbiology, Hospital Universitari de Bellvitge. IDIBELL, Department of Pathology and Experimental Therapeutics, Universitat de Barcelona, Barcelona, Spain.; 2. Department of Infectious Diseases, Hospital Universitari de Bellvitge. IDIBELL, Department of Pathology and Experimental Therapeutics, Universitat de Barcelona, Barcelona, Spain.; Universitätsklinikum Hamburg-Eppendorf, Germany, |
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| Abstract: | Linezolid is an effective antimicrobial agent to treat methicillin-resistant Staphylococcus aureus (MRSA). Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr–mediated linezolid resistance among MRSA clinical isolates in our area. A very low prevalence of cfr mediated linezolid resistance was found: only one bacteremic isolate out of 2 215 screened isolates. The only linezolid resistant isolate arose in a patient, previously colonized by MRSA, following linezolid therapy. Despite the low rate of resistance in our area, ongoing surveillance is advisable to avoid the spread of linezolid resistance. |
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