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T cell cytoskeletal forces shape synapse topography for targeted lysis via membrane curvature bias of perforin
Institution:1. EMBL Australia, Single Molecule Science node, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia;2. Cellular and Systems Physiology, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Abstract:
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  • Keywords:cytotoxic T cells  perforin  mechanobiology  immunological synapse  dynein  actomyosin  cytoskeleton  cell polarization  lytic granules
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