Breakage of Chromosomal DNA with Aromatic Reductones |
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Authors: | Hiroki Murakami Toshihiro Miyoshi Michiko Koga Koji Yamada Hirohisa Omura |
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Institution: | 1. Food Chemistry Institute, Faculty of Agriculture, Kyushu University, Fukuoka;2. Cancer Research Institute, Faculty of Medicine, Kyushu University, Fukuoka |
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Abstract: | Strand breakages of mammalian cellular chromosomal DNA with aromatic reductones were ascertained by use of a cultured cell strain of the rat fetal lung (RFL). The mode of the breakages was investigated by ultracentrifugal analyses. The reductones induced the breakages of the cellular DNA in two different fashions; one is single strand breaks and another double strand breaks. Although the single strand breaks were rapidly repaired, double strand breaks were only partially repaired. Both breaks were not cytocidal. Some physiological alterations were observed to follow the strand breaks. |
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Keywords: | acetylacetoin acetylacetoin synthase acetoin diacetyl 2 3-butanediol cycle |
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