Accumulation of S-Adenosylmethionine by Molds |
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Authors: | Hitoshi Kusakabe Akira Kuninaka Hiroshi Yoshino |
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Institution: | Research Laboratory, Yamasa Shoyu Co., Ltd., Choshi |
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Abstract: | Aspergillus tamani accumulated about 20 μmoles of S-adenosylmethionine (SAM) in 1 g of dry cells when cultured secondarily in a medium containing more than 10 mm of l- methionine. The accumulation was not so high when l-methionine was replaced by d- methionine. Addition of nucleic acid-related substances was not effective for the accumulation. Addition of d, l-ethionine in place of methionine caused accumulation of S-adenosylethionine (SAE) in place of SAM. Among 100 strains of molds tested, a number of strains belonging to the genera Penicillium, Aspergillus, Rhizopus and Mucor could accumulate SAM in their mycelia. Especially Mucor jansseni had the highest ability; it accumulated 45 μmoles of SAM in 1 g of dry cells. |
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Keywords: | (-)-indolactam-V malonic acid conjugate Streptomyces blastmyceticum teleocidin tumor promoter |
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