Optical Rotatory Dispersion of Rotundifolone |
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Authors: | Sumio Shimizu Jun Katsuhara Yuzo Inouye |
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Institution: | 1. Department of Agriculture, Shinshu Univerity, Ina, Nagano;2. Research Labortories, Sun Star Dentifrice Co. Ltd., Takatsuki;3. Institute for Chemical Research, Kyoto University, Takatsuki, Osaka |
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Abstract: | Microbial (enzymatic) hydrolysis of (±)-O-acetyl allethrolone gave (?)-(R)-allethrolone with (+)-(S)-O-acetyl allethrolone. And microbial hydrolysis of (±)-cis and trans-2-allylcyclopentyl acetates gave the low optically active cis and trans-2-allylcyclopentanols with the acetates of their antipodes. Also, the acetates of (±)-primary alcohols with cyclopropane and cyclohexene rings: (±)-chrysanthemyl alcohol, α-cyclogeraniol, were hydrolyzed by microorganisms to give the optically active alcohols in low optical purities Further, synthesis and microbial resolution of racemic hydroxy-trimethylcyclohexanones, useful intermediate for synthesis of compounds related to carotenoids, were tried. |
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Keywords: | mass spectrometric analysis site-directed mutagenesis active site penicillin-binding proteins general base |
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