Inhibitory effect of 13 taxane diterpenoids from Chinese yew (Taxus chinensis var. mairei) on the proliferation of HeLa cervical cancer cells |
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| Authors: | Hai-Sheng Liu Yu-Huan Gao Li-Hong Liu Qing-Wen Shi |
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| Affiliation: | 1. Department of Hematology, Fourth Hospital of Hebei Medical University, Shijiazhuang, China;2. Department of Forensic Medicine, Hebei Medical University, Shijiazhuang, China |
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| Abstract: | The inhibitory effect of 13 taxanes isolated from the Chinese yew (Taxus chinensis var. mairei) on the proliferation of human cervical cancer HeLa cells were examined using an MTT assay. Four compounds having a hydrophobic cinnamate side chain showed antiproliferative activity, which may be due to increased cell permeability. |
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| Keywords: | Taxus chinensis var. mairei taxanes HeLa cells antiproliferative activity apoptosis |
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