Phosphorylation of filamin (ABP-280) regulates the binding to the lipid membrane, integrin, and actin |
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Authors: | Goldmann W H |
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Affiliation: | Department of Pathology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. wgoldmann@partners.org |
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Abstract: | Actin-binding protein (ABP-280; filamin) is a phosphoprotein present in the periphery of the cytoplasm, where it can cross-link actin filaments, associate with lipid membranes, and bind to membrane surface receptors. Given its function and localization in the cell, the hypothesis that it serves as a substrate for p56lck, a lymphocyte-specific member of the src family of protein tyrosine kinases associated with cell surface glycoproteins is considered. The results suggest conformationally-induced regulation of filamin (ABP-280). |
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Keywords: | tyrosine phosphorylation filamin (ABP‐280) actin integrin lipid membrane |
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