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Anti-malarial activity of Baylis-Hillman adducts from substituted 2-chloronicotinaldehydes |
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| Authors: | Narender P Srinivas U Gangadasu B Biswas Sukla Rao V Jayathirtha |
| Affiliation: | aOrganic Chemistry Division-II, Indian Institute of Chemical Technology,Uppal Road, Tarnaka, Hyderabad 500007, India bMalaria Research Center, 22 Sham Nath Marg, Delhi 110054, India |
| Abstract: |  New Baylis–Hillman adducts are synthesized based on substituted 2-chloronicotinaldehydes and screened for their in vitro anti-malarial activity against chloroquine sensitive and chloroquine resistant Plasmodium falciparum. Out of the six new compounds synthesized and screened, 2b, 2c and 2d compounds showed substantial anti-malarial activity. |
| Keywords: | Substituted 2-chloronicotinaldehydes Baylis–Hillman adducts Anti-malarial activity |
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