网状内皮增生病病毒感染SPF鸡对疫苗免疫反应的抑制作用

我国鸡群中网状内皮增生病病毒(REV)感染已相当普遍,但对其造成的实际危害却不太清楚。本研究结果表明,1日龄SPF鸡感染REV会显著抑制对新城疫病毒(NDV)和禽流感病毒(AIV,H5和H9)疫苗的免疫反应。1周龄用相应灭活疫苗免疫后3周、4周和5周,REV感染组对不同病毒疫苗免疫后的HI效价显著低于对照组。高剂量REV感染组的抑制作用大于低剂量感染组,但统计学差异不显著。REV感染可造成中枢免疫器官萎缩,REV感染组的胸腺、法氏囊与体重比显著低于对照组。本研究证明了,REV早期感染会干扰鸡群对NDV、AIV的免疫效果,特别是会严重干扰对AIV疫苗的免疫效果。

Immuno-Suppression of Reticuloendotheliosis Virus Infection on Antibody Responses to Different Vaccines in SPF chickens

Avian reticuloendotheliosis virus(REV)infection was reported to be very common in chicken flocks in China,but its economic impact on the poultry industry was not clear.The results in this study indicated that REV infection in 1-day-old SPF chickens could severely suppressimmune reactions to inactivated vaccines against Newcastle disease virus(NDV)and Avian influenza virus(AIV).Hemagglutination inhibition(HI)antibody titers to NDV,AIV-H9 and AIV-H5 in REV-infected birds were significantly lower than that in the control group 3,4,and 5 weeks after vaccination at the age of 7 days.REV infection of high doses caused more severely immuno-suppression than that with low doses,but the difference between high and low doses was not significant.REV infection also caused severe atrophy of central immune organs,the ratios of thymus and the Bursa to body weight in REV-infected birds were significantly lower than that in thecontrol birds.This study demonstrated that the early REV-infection interfered vaccinations to NDV and AIV.